Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common causes of anovulatory infertility. Polymorphisms in genes related to follicular recruitment and development, such as the follicle-stimulating hormone receptor (FSHR) and the oestrogen receptor 1 (ESR1) genes, and their impact on biochemical phenotype and response to controlled ovarian stimulation in women with PCOS have been studied in different populations, with inconsistent results.<p class="abstext...

Background: The detection of thyroid incidental uptake of radiopharmaceuticals has been increasing. Those detected by 18F-fluorodeoxyglucose positron emission tomography (PET) have been associated with a significant risk of malignancy (8–64%). Gallium-68 (Ga-68) labelled peptides are now the standard imaging modality for staging neuroendocrine tumours (NET). Its high sensitivity has increased the discovery of incidental findings. The aim of this study was to ev...

Background: Diabetes mellitus is mainly characterized by a dysfunction of glucose metabolism. The growth of diabetes mellitus as a chronic condition requires continuous management and requires health services to implement care strategies. Diabetes education and self-care competence have been recognized over the last few decades as essential for patients with diabetes mellitus to achieve positive treatment results.Objective: To compare self-care competenc...

Introduction: Obesity is a pathological condition characterized by a low-grade systemic inflammatory state that predisposes to the onset of some diseases, such as hypertension, diabetes, and hyperlipidemia. Also, obesity can impact bone metabolism, but its effects are controversial.Aims: This observational study aimed to evaluate and correlate the bone mass with the lipidic profile, adipocytokines, glucose metabolism, hepatic function and purine metaboli...

Introduction: Sex steroid hormones play a key role in bone health, however medical therapies for gender dysphoria lead to hormonal changes.Purpose: Understanding the change in bone mass and body composition is extremely important, because this treatment will be carried out over a long period of timeMethods: In a prospective study, we included 19 transgender men (female-to-male trans persons) before treatment and after 1 year of tre...

Introduction: Polycystic ovary syndrome (PCOS) is a frequent cause of infertility. Its influence on the results of in vitro fertilization (IVF) is controversial, and generally not isolated from the effect of obesity. A relationship between the FSH receptor (FSHR) polymorphism Asn680Ser and the risk and phenotype of PCOS has been studied with conflicting results.Objectives: To analyze the influence of obesity and PCOS on the gonadal axis...

Introduction: Immunotherapy has demonstrated a key role in the current individualized treatment of multiple neoplasms, with adverse events related to the endocrine. Thyroid dysfunction is the most frequent reported endocrine event during treatment with pembrolizumab, being autoimmune diabetes an extremely rare adverse effect.Case Report: We present a case of a 72-year-old man with a progressing urothelial bladder carcinoma (stage IIIB), under treatment w...

Background: Children who were born small for gestational age (SGA) and who do not have adequate catch-up growth until 4 years old have indication for treatment with recombinant human growth hormone (rhGH). The metabolic consequences of this treatment are relatively unknown. Objective: To evaluate the effect of rhGH treatment on insulin sensitivity and lipid profile.Materials and methods: A retrospective observational study of child...

Introduction: Riedel’s thyroiditis (RT) is a rare chronic inflammatory disease characterized by a dense fibrosis that replaces normal thyroid parenchyma. The most common manifestation is a stony hard thyroid mass, commonly associated with compressive symptoms. Histological confirmation is essential for diagnosis and the main differential diagnosis is the anaplastic thyroid cancer. The management is challenging and there is no agreed standard treatment, since only a few ca...

Background: Pheochromocytoma is a rare catecholamine secreting tumor originating usually from adrenal medulla and representing approximately 5% of adrenal incidentalomas. Currently 10% of all pheochromocytomas are discovered incidentally during imaging studies for unrelated disorders.Case presentation: A thirty five year old woman with no relevant medical history presented at the emergency department with symptoms of left flank pain and vomiting. Abdomin...